Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II.
Chlorambucil therapy in postsplenectomy patients with progressive disease
HM Golomb and U Mintz
Four postsplenectomy patients with progressive hairy cell leukemia were
treated with daily low doses of an alkylating agent (chlorambucil, 4 mg).
An objective response, measured by improvement in blood counts in four
patients as well as decreased bone marrow involvement on core biopsy in
three patients, could be documented within 6 mo. It is important to
identify the postsplenectomy patient with progressive disease as early as
possible in order to initiate low-dose single agent chemotherapy and have
the time necessary to effect an objective response.
Volume 54,
Issue 2,
pp. 305-309,
08/01/1979
Copyright © 1979 by The American Society of Hematology
