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TH Price, MY Lee, DC Dale and CA Finch
Quantitative studies of bone marrow neutrophil pool sizes and production
rates and of blood neutrophil kinetics were performed in 16 patients with
chronic neutropenia without splenomegaly. Marrow netrophil cellularity was
determined from a ferrokinetic estimate of marrow normoblasts and from
neutrophil-erythroid ratios determined from marrow sections. Postmitotic
pool turnover was derived from the postmitotic pool size and transit time,
the latter determined from 3H- thymidine neutrophil emergence time. Blood
neutrophil kinetics were studied with 32P-diisopropylfluoophosphate-labeled
autologous neutrophils. Mitotic pool size was basal or below basal in 12 of
the 16 patients. The turnover of the post-mitotic neutrophils was subbasal
in 6, basal in 7, and above basal in 3 patients. Blood neutrophil turnover
was within the normal range in 8 patients and decreased in 8. The degree of
ineffective granulocytopoiesis was assessed by comparing the relative size
of the mitotic pool, postmitotic pool turnover, and blood turnover. On this
basis, 13 of the 16 patients showed appreciable degrees of ineffective
granulocytopoiesis. Ineffective neutrophil production occurred both early
and late in neutrophil development. These studies indicate that most
patients with chronic neutropenia without splenomegaly lack a proliferative
marrow response to the neutropenia and suggest that ineffective
granulocytopoiesis is a common feature of this disorder.
This article has been cited by other articles:
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| Copyright © 1979 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
