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ABO compatibility and platelet transfusions of alloimmunized thrombocytopenic patients

RJ Duguesnoy, AJ Anderson, PA Tomasulo and RH Aster

With data on 91 alloimmunized thrombocytopenic patients and 389 donor- recipient pairs matched or selectively mismatched for HLA antigens, it was observed that ABO incompatibility significantly reduced the effectiveness of platelet transfusions. The mean 24-hr recovery of platelets from histocompatible donors and from donors selectively mismatched for cross-reactive HLA antigens was decreased by approximately 23% if the donor typed for blood group A and/or B not found in the recipient. Thus, the reduction in platelet recovery associated with ABO incompatibility is not of a magnitude that would contraindicate transfusion of ABO-mismatched platelets.

Volume 54, Issue 3, pp. 595-599, 09/01/1979
Copyright © 1979 by The American Society of Hematology


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