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Hand-mirror cell leukemia associated with mental retardation: immunologic, chromosome, and morphological studies

R Stern, ST Widirstky, DH Wurster-Hill, RD Allen, KA Smith, GG Cornwell and CJ Cornell

Cycochemical, morphological, immunologic, and cytogenetic studies were carried out on hand-mirror cells (HMC) from a mentally retarded patient with a constitutional chromosome abnormality, 46,XX,r(21), and acute lymphoblastic leukemia. Scanning electron and differential interference contrast microscopy showed microspikes on the uropodia, but little evidence of cellular motility, despite formation and disappearance of individual uropodia in cell suspensions. The cells rosetted with sheep erythrocytes, suggesting T-cell origin. Cells derived from the bone marrow (80% HMC) showed a high degree of polyploidy (60%) and a bimodal chromosome number of 49 (49,XX,+10,-21, +3 rings) and 94 (6 no. 10, 3 no. 18, 2 no. 21 chromosomes, 3 ring chromosomes, plus 4 copies of each other chromosome).

Volume 54, Issue 3, pp. 703-712, 09/01/1979
Copyright © 1979 by The American Society of Hematology


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 Arch Intern MedHome page
R. E. Smith
Hand-Mirror-Cell Variant of B-Cell Lymphoma With Hypercalcemia
Arch Intern Med, November 1, 1986; 146(11): 2273 - 2274.
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