Antibody-mediated acquired sideroblastic anemia: response to cytotoxic
therapy
AK Ritchey, R Hoffman, N Dainiak, S McIntosh, R Weininger and HA Pearson
A 5 1/2-yr-old child developed severe anemia with erythroid hypoplasia and
50% ringed sideroblasts in his bone marrow. A serum inhibitor of
erythropoiesis was demonstrated, utilizing syngeneic and autologous bone
marrow in a plasma-clot culture system. The IgG fraction of the patient's
serum effected similar suppression of erythroid colony formation.
Prednisone therapy was ineffective, but following treatment with
cyclophosphamide, normal erythropoiesis was established, ringed
sideroblasts disappeared, and his serum no longer inhibited erythropoiesis
in vitro. Cyclophosphamide was discontinued, and the patient has remained
hematologically normal. This patient is an example of antibody-mediated
sideroblastic anemia successfully treated with a cytotoxic drug.
Volume 54,
Issue 3,
pp. 734-741,
09/01/1979
Copyright © 1979 by The American Society of Hematology
