Thrombocytosis-induced suppression of small acetylcholinesterase- positive
cells in bone marrow of rats
MW Long and RL Henry
Transfusion of platelet concentrates was used to establish a thrombocytosis
of approximately three times normal platelet levels in male rats. This
thrombocytosis resulted in a rebound thrombocytopenia to 60% of normal
counts. Examination of the small acetylcholinesterase (ACh-E) positive
cells of the marrow at this time showed a reduction to 50% of normal levels
without significant changes in control animals. A second group of
experiments indicated that this suppression developed as early as the third
day posttransfusion, persisted until day 7, and returned to baseline levels
by day 9. Incorporation of 75SeM indicated that the reduction in platelet
count was due to decreased platelet production. Little or no changes were
observed in the hematocrit or WBC. This evidence supports the hypothesis
that these cells are early cells in the megakaryocytic series. They are the
earliest cells of the series seen to be affected by thrombocytosis.
Feedback control by platelets or platelet extracts of this cell population
may represent one level of regulation of megakaryopoiesis.
Volume 54,
Issue 6,
pp. 1338-1338,
12/01/1979
Copyright © 1979 by The American Society of Hematology
