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Plasma concentrations of platelet-specific proteins correlated with
platelet survival
DJ Doyle, CN Chesterman, JF Cade, JR McGready, GC Rennie and FJ Morgan
Relationships between 51Cr platelet survival and plasma concentrations of
beta-thromboglobulin (betaTG) and platelet factor 4 (PF4) were analyzed in
91 studies of patients with coronary artery disease. betaTG was
significantly correlated with platelet life-span, turnover, and the number
of hits in the multiple hit model. PF4 was significantly correlated with
life-span and turnover. The most significant relationship involving
platelet-specific protein concentrations and life-span estimates was
between betaTG and life-span estimated using the multiple hit model (r =
-0.39, p less than 0.001). There was a high correlation between betaTG and
PF4 (r = 0.62, p less than 0.001), and no improvement could be obtained by
combining the measurements of the two proteins in any regression with
life-span or turnover. The results indicate that the patients with the
shortest platelet survival time in this group tended to have the highest
plasma concentration of betaTG and PF4 and thus probably increased in vivo
release of betaTG and PF4. They strengthen the claim that these
platelet-specific proteins may be indicators of platelet involvement in
disease.
Volume 55,
Issue 1,
pp. 82-84,
01/01/1980
Copyright © 1980 by The American Society of Hematology
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