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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brittenham, G. Articles by Nayudu, N. V. Search for Related Content PubMed PubMed Citation Articles by Brittenham, G. Articles by Nayudu, N. V. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents Alpha globin gene number: population and restriction endonuclease studies G Brittenham, B Lozoff, JW Harris, YW Kan, AM Dozy and NV Nayudu Restriction endonuclease analysis was used to test a proposed genetic model using alpha-globin gene number to account for the observed distributions of the proportions of hemoglobin (Hb) S in sickle cell trait. In a subsample of specimens collected during a population survey in India, these studies confirmed that the postulated genotype was present in 22 of the 23 individuals examined. In the study population, the number of alpha-globin genes explains about 90% of the variance in the proportion of HbS in sickle cell trait (r2 = 0.895, p less than 10(- 10)). Volume 55, Issue 4, pp. 706-708, 04/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C E Head, M Conroy, M Jarvis, L Phelan, and B J Bain Some observations on the measurement of haemoglobin A2 and S percentages by high performance liquid chromatography in the presence and absence of {alpha} thalassaemia J. Clin. Pathol., March 1, 2004; 57(3): 276 - 280. [Abstract] [Full Text] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020