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Chronic myelocytic leukemia: eosinophils involved in the malignant clone

HP Koeffler, AM Levine, M Sparkes and RS Sparkes

Chronic myelocytic leukemia (CML) is a clonal disorder involving neutrophil, monocyte, erythrocyte, and platelet precursors. In order to determine if the eosinophils are also involved in the leukemic clone, we purified the eosinophils from a woman heterozygous for the common electrophoretic variants of the G6PD gene. Only type B enzyme was demonstrable in the eosinophils, neutrophils, and red cells, but both A and B enzymes were found in the fibroblasts. The data provide evidence that the eosinophil is involved in the malignant clone.

Volume 55, Issue 6, pp. 1063-1065, 06/01/1980
Copyright © 1980 by The American Society of Hematology


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