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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Phillips, J. 3. Articles by Koenig, H. M. Search for Related Content PubMed PubMed Citation Articles by Phillips, J. 3. Articles by Koenig, H. M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Unequal crossing-over: a common basis of single alpha-globin genes in Asians and American blacks with hemoglobin-H disease JA Phillips , TA Vik, AF Scott, KE Young, HH Kazazian , KD Smith, VF Fairbanks and HM Koenig The alpha-globin genes of five black Americans, two Chinese, and five Filipinos with HbH disease (an alpha-thalassemia state in which there is a single functional alpha gene) were analyzed by restriction endonuclease techniques. All subjects were found to have one chromosome 16, lacking both alpha genes, and another containing a single alpha gene (--/-alpha). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single alpha gene in these individuals. Volume 55, Issue 6, pp. 1066-1069, 06/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J.A. BAILEY and E.E. EICHLER Genome-wide Detection and Analysis of Recent Segmental Duplications within Mammalian Organisms Cold Spring Harb Symp Quant Biol, January 1, 2003; 68(0): 115 - 124. [Abstract] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020