Effect of hypertransfusion on bone marrow regeneration in sublethally
irradiated mice. II. Enhanced recovery of megakaryocytes and platelets
PJ Smith, CW Jackson, MA Whidden and CC Edwards
Hypertransfusion can enhance myeloid recovery after bone marrow depletion,
but its influence on thrombopoietic recovery has not been previously
defined. We have studied the pattern of platelet and megakaryocyte recovery
in mice hypertransfused after receiving 350 rad whole body irradiation. The
platelet counts of the hypertransfused group showing an initial fall due to
hemodilution in the expanded blood volume and then fell to a lower nadir
than that of the control mice. The rate of platelet recovery was more rapid
in the hypertransfused mice. Bone marrow megakaryocyte concentrations in
both groups showed a degenerative phase, abortive rise, and regenerative
phase. The decrease in megakaryocytes was the same in both groups. The
hypertransfused mice showed a greater abortive rise in megakaryocyte
concentration preceded by the appearance of a greater number of large
megakaryocytes in the bone marrow. However, the most striking effect of
hypertransfusion was on megakaryocyte recovery. Although the time of onset
of recovery was not different, the rate of recovery was approximately twice
as rapid in the hypertransfused group. Administration of daily
erythropoietin to hypertransfused mice abolished this more rapid recovery.
Thus, the presence of a simultaneous demand for erythroid precursors does
affect the rate of megakaryocyte regeneration. Just as the more rapid
recovery of granulopoiesis following hypertransfusion may be clinically
beneficial, the more rapid reconstitution of thrombopoiesis may also offer
clinical advantage in some circcumstances.
Volume 56,
Issue 1,
pp. 58-63,
07/01/1980
Copyright © 1980 by The American Society of Hematology
