Prediction of response to chemotherapy in acute myelocytic leukemia
HD Preisler
Marrow specimens obtained from 23 patients with acute myelocytic leukemia
were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the
effects of these agents on colony formation in vitro was determined.
Thymidine suicide indices were determined as well, which permitted a
distinction to be made between kinetic and metabolic resistance to cytosine
arabinoside. The sensitivity of the colony- forming cells to the two
chemotherapeutic agents did not correlate with each other, indicating that
sensitivity to each was independently determined. The relationship between
in vitro sensitivity to daunorubicin and cytosine arabinoside and response
to 25 courses of in vivo therapy with these two agents administered to 21
patients was determined. These studies indicated a clear-cut relationship
between in vitro drug sensitivity and in vivo response with patients whose
leukemic cells were sensitive to both agents entering complete remission,
whereas patients whose leukemic cells were insensitive to one or both drugs
in vitro failed to enter remission.
Volume 56,
Issue 3,
pp. 361-367,
09/01/1980
Copyright © 1980 by The American Society of Hematology
