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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vicic, W. J. Articles by Weiss, H. J. Search for Related Content PubMed PubMed Citation Articles by Vicic, W. J. Articles by Weiss, H. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Release of human platelet factor V activity is induced by both collagen and ADP and is inhibited by aspirin WJ Vicic, B Lages and HJ Weiss Factor V activity in suspensions of human platelets washed by albumin density gradient separation increased in response to stimulation by both collagen and adenosine diphosphate (ADP). The appearance of factor V activity extracellularly had the characteristics of platelet secretion and was partially inhibited by aspirin and by the antimetabolites 2-deoxyglucose and antimycin A. Some increase in factor V activity was also observed in platelet suspensions during the initial response to ADP; this activity was not detected extracellularly, but remained associated with the platelets. Patients with storage pool deficiency (SPD) whose platelets are deficient only in dense granule substances released normal amounts of factor V activity, whereas decreased amounts were released in a patient whose platelets have both dense and alpha granule deficiencies. These findings suggest that a portion of platelet factor V is associated with, and released from, alpha granules. Volume 56, Issue 3, pp. 448-455, 09/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. R. Gould, J. R. Silveira, and P. B. Tracy Unique in Vivo Modifications of Coagulation Factor V Produce a Physically and Functionally Distinct Platelet-derived Cofactor: CHARACTERIZATION OF PURIFIED PLATELET-DERIVED FACTOR V/Va J. Biol. Chem., January 23, 2004; 279(4): 2383 - 2393. [Abstract] [Full Text] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020