Result of attempted hematopoietic reconstitution using isologous,
peripheral blood mononuclear cells: a case report
RA Abrams, D Glaubiger, FR Appelbaum and AB Deisseroth
In order to test the effect of peripheral blood mononuclear cell infusions
on hematopoietic recovery in man we intensively leukapheresed a normal
identical twin and obtained 9.8 x 10(10) peripheral blood mononuclear cells
containing 4 x 10(5) CFU-C. These isologous cells were infused into his
identical twin brother who had received 150 rad of total body irradiation
and intensive combination chemotherapy as adjuvant therapy for Ewing's
sarcoma. When compared to other patients receiving similar treatment,
leukocyte recovery was accelerated by 3-4 wk, and occurred at a rate
comparable to that induced by infusion of autologous cryopreserved marrow.
Recovery of granulocytes, monocytes and platelets was not accelerated. The
low number of CFU-C present in the preparation used ((one-eighth the number
of CFU-C we usually obtain from bone marrow autograft collections) may have
led to the pattern of hematopoietic recovery we observed in this patient.
Volume 56,
Issue 3,
pp. 516-520,
09/01/1980
Copyright © 1980 by The American Society of Hematology
