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Ultrastructural evidence for the common origin of human mast cells and
basophils
D Zucker-Franklin
Although the functional similarity of basophils and mast cells is widely
accepted, their distinctive morphological features have been taken to
indicate the existence of two different, albeit functionally complementary,
cell systems. The recent demonstration that mast cells as well as basophils
originate from the bone marrow raises the possibility that these cells
derive from the same precursor. This report provides evidence for this
theory by describing a distinctive "intermediate" cell possessing the
ultrastructural features typical of both basophils and mast cells. These
cells were encountered in three patients with myeloproliferative diseases
and may thus be more readily found in states of disturbed myelopoiesis.
These observations have given impetus for the first comparative description
of the ultrastructure of human basophils, human mast cells, and the newly
recognized intermediate cell within a single report.
Volume 56,
Issue 3,
pp. 534-540,
09/01/1980
Copyright © 1980 by The American Society of Hematology
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