SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mitchell, B. S. Articles by Heyn, R. Search for Related Content PubMed PubMed Citation Articles by Mitchell, B. S. Articles by Heyn, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo BS Mitchell, CA Koller and R Heyn We have treated a patient with refractory T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin, a potent inhibitor of the enzyme adenosine deaminase. Inhibition of adenosine deaminase activity resulted in (1) an abrupt rise in plasma deoxyadenosine, but not adenosine, concentrations; (2) accumulation of deoxyadenosine triphosphate by lymphoblasts; (3) inhibition of the enzyme S- adenoylhomocysteine hydrolase; and (4) rapid lysis of the leukemic cells. The patient died suddenly 3 days after therapy was discontinued, and postmortem examination revealed a complete absence of leukemic cells in all organs. Pharmacologic inhibition of adenosine deaminase activity can result in the lysis of T lymphoblasts in vivo, and this effect appears to be mediated by deoxyadenosine. Volume 56, Issue 3, pp. 556-559, 09/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. J. O'DWYER, B. WAGNER, B. LEYLAND-JONES, R. E. WITTES, B. D. CHESON, and D. F. HOTH 2'-Deoxycoformycin (Pentostatin) for Lymphoid Malignancies: Rational Development of an Active New Drug Ann Intern Med, May 1, 1988; 108(5): 733 - 743. [Abstract] [PDF] M. Hershfield and U Francke The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20 Science, May 14, 1982; 216(4547): 739 - 742. [Abstract] [PDF] I. Kazmers, B. Mitchell, P. Dadonna, L. Wotring, L. Townsend, and W. Kelley Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts Science, December 4, 1981; 214(4525): 1137 - 1139. [Abstract] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020