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JE Sokal
Fifty-six of 195 Ph1-positive patients with chronic granulocytic leukemia
were found to have Ph1-negative metaphases in marrow aspirates on one or
more occasions. In 22 cases, Ph1-negative cells were found prior to
initiation of antileukemic therapy. Five patients were in the blastic stage
of the disease when Ph1-negative mitoses were seen. The finding of
Ph1-negative cells appeared to be related principally to short duration of
CGL and to administration of antileukemic therapy (conventional agents and
doses, in most cases). Ph1-negative cells were usually not found more than
2 yr after the diagnosis of leukemia, but in a few cases, they were seen as
long as 5-10 yr after diagnosis. Only a minority of metaphases analyzed
were Ph1-negative, except in the case of 6 patients who transiently had 50%
or more Ph1-negative cells after antileukemic therapy. The presence of
Ph1-negative cells in marrow was not associated with any survival advantage
in this series.
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| Copyright © 1980 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
