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The mechanism of platelet release
JM Radley and G Scurfield
The mechanism of platelet release has been studied in mouse bone marrow,
using scanning and transmission electron microscopy. Cytoplasmic processes
extended into sinusoids by megakaryocytes were found to undergo
attenuation, and at the distal end develop constrictions between segments
of platelet size. Rupture at sites of constriction is thought to release
platelets. Microtubules were present in the processes, orientated
longitudinally, and became concentrated in the constrictions. The narrowest
constrictions observed were about 0.2 micrometer in diameter and several
microns in length. The structural similarity of the narrowest constrictions
with those found in bridges separating midbody and cell in the terminal
phase of cytokinesis suggests that platelets and cells share a common
mechanism for release. The presence of a centriole in each cytoplasmic
process was revealed by serial sectioning. It is suggested that the
microtubules in each cytoplasmic process originate from an organizing
center associated with the centriole, and that the number of cytoplasmic
processes that emerge from a megakaryocyte is governed by its ploidy.
Volume 56,
Issue 6,
pp. 996-999,
12/01/1980
Copyright © 1980 by The American Society of Hematology
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