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EM Huang and TC Detwiler
Platelets are activated by many different agonists that act
synergistically. Since there is a characteristic pattern of responses to
each agonist, and since there is a clear distinction between weak and
strong agonists, understanding the nature of the synergism and its
physiologic significance requires characterization of the pattern of
responses to the synergistic action of the various agonists. Shape change,
aggregation, and secretion of ATP by human platelets in citrated plasma
were analyzed after activation by ADP, epinephrine, arachidonic acid,
gamma-thrombin, or collagen, either singly or in pairs. The patterns of
responses were characteristic of the agonist in higher concentration
relative to its threshold concentration; if neither was clearly higher, the
pattern of responses was intermediate between the responses characteristic
of each agonist. No combination of weak agonists had the characteristics of
a strong agonist. These results help define the extent to which platelet
responses can be attributed to the synergistic actions of weak agonists.
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| Copyright © 1981 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
