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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tidwell, T. Articles by Vogler, W. R. Search for Related Content PubMed PubMed Citation Articles by Tidwell, T. Articles by Vogler, W. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The effects of alkyl-lysophospholipids on leukemic cell lines. I. Differential action on two human leukemic cell lines, HL60 and K562 T Tidwell, G Guzman and WR Vogler The action of an alkyl-lysophospholipid (ALP), ET180CH3, on clonogenicity, 3H-TdR uptake, and cell numbers was tested in two human leukemic cell lines, HL60 and K562, and short-term human leukemic bone marrow cultures. ALP eliminated clonogenicity in HL60 but not in K562 cultures; 3H-TdR uptake and cell numbers were depressed at low concentrations of ET180CH3 in HL60, but not K562 cultures. The action of the lysophospholipid analog on human leukemic bone marrow short-term cultures at low concentrations was similar to its action on HL60 cultures; clonogenicity and 3H-TdR uptake were depressed, but cell numbers were not significantly affected. The demonstration of differential action of ALP on two cell lines should significantly simplify the investigation of the mechanism of the reported differential action of ET180CH3 on normal and leukemic cell membranes. Volume 57, Issue 4, pp. 794-797, 04/01/1981 Copyright © 1981 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Gajate, A. Santos-Beneit, M. Modolell, and F. Mollinedo Involvement of c-Jun NH2-Terminal Kinase Activation and c-Jun in the Induction of Apoptosis by the Ether Phospholipid 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine Mol. Pharmacol., April 1, 1998; 53(4): 602 - 612. [Abstract] [Full Text] J. S. Liou, C.-Y. Chen, J. S. Chen, and D. V. Faller Oncogenic Ras Mediates Apoptosis in Response to Protein Kinase C Inhibition through the Generation of Reactive Oxygen Species J. Biol. Chem., December 8, 2000; 275(50): 39001 - 39011. [Abstract] [Full Text] [PDF]

	Copyright © 1981 by American Society of Hematology         Online ISSN: 1528-0020