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K Pavelic, J Gabrilovac, V Bozikov, J Pavelic, M Petek and M Boranic
Daily injections of somatostatin into mice with myeloid leukemia retarded
the tumor growth. This myeloid leukemia is an insulin- dependent tumor (in
that it grows more slowly in hypoinsulinemic diabetic mice than in
nondiabetic animals). Since somatostatin decreased the level of
immunoreactive insulin in mice with myeloid leukemia, and since the
treatment with insulin abrogated the antileukemic effect of somatostatin,
we attribute retarded growth of this leukemia to decreased secretion of
insulin, caused by somatostatin.
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| Copyright © 1981 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||