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BS Morse, D Giuliani and M Nussbaum
Platelet-associated IgG (PAIgG) was measured by a simple radial
immunodiffusion technique using washed solubilized platelets and
commercially available immunoplates. Subjects with normal platelet counts
had PAIgG levels of 1.5--7.0 fg/platelet. Subjects with idiopathic immune
thrombocytopenic purpura (ITP) had levels ranging from 5.7 to 70.5
fg/platelet. All patients with recurrent ITP and 85% of patients with acute
ITP had elevated PAIgg. Elevated PAIgG was also found in 17% of patients
with recovered ITP, 40% of patients with SLE and thrombocytopenia, 57% of
patients with thrombocytopenia occurring during the course of septicemia,
and 100% of patients with IgG myeloma in whom the serum IgG level was
clearly elevated, regardless of the platelet count. The results are similar
to reports that used more complex techniques.
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| Copyright © 1981 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||