|
|
 Previous Article | Table of Contents | Next Article 
Terminal differentiation of human promyelocytic leukemic cells in primary
culture in response to retinoic acid
TR Breitman, SJ Collins and BR Keene
The recent finding that retinoic acid induces terminal granulocytic
differentiation of the human promyelocytic leukemia cell line, HL-60,
prompted an investigation of the sensitivity to this inducer of human
myelocytic leukemia cells in primary suspension culture. Of the 21 leukemic
specimens, only cells from the two patients with acute promyelocytic
leukemia differentiated in response to retinoic acid. After an incubation
period of 5--7 days in 1 microM retinoic acid, the cells from these two
patients showed extensive morphological and functional maturation. Thus,
because it appears that retinoic acid specifically induces granulocytic
differentiation of leukemic promyelocytes, this compound may have
therapeutic utility in the treatment of acute promyelocytic leukemia.
Volume 57,
Issue 6,
pp. 1000-1004,
06/01/1981
Copyright © 1981 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. Nowak, D. Stewart, and H. P. Koeffler
Differentiation therapy of leukemia: 3 decades of development
Blood,
April 16, 2009;
113(16):
3655 - 3665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-Y. Wang and Z. Chen
Acute promyelocytic leukemia: from highly fatal to highly curable
Blood,
March 1, 2008;
111(5):
2505 - 2515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Tallman and J. K. Altman
Curative Strategies in Acute Promyelocytic Leukemia
Hematology,
January 1, 2008;
2008(1):
391 - 399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-B. Zhou, J. Zhang, Z.-Y. Wang, S.-J. Chen, and Z. Chen
Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy
Phil Trans R Soc B,
June 29, 2007;
362(1482):
959 - 971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Kubo, M. Wada, T. Ohba, and N. Takahashi
Formation of Retinoylated Proteins from Retinoyl-CoA in Rat Tissues
J. Biochem.,
October 1, 2005;
138(4):
493 - 500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Heuze, F. C. Guibal, C. A. Banks, J. W. Conaway, R. C. Conaway, Y. E. Cayre, A. Benecke, and P. G. Lutz
ASB2 Is an Elongin BC-interacting Protein That Can Assemble with Cullin 5 and Rbx1 to Reconstitute an E3 Ubiquitin Ligase Complex
J. Biol. Chem.,
February 18, 2005;
280(7):
5468 - 5474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N. Harris, B. Ozpolat, F. Abdi, S. Gu, A. Legler, K. G. Mawuenyega, M. Tirado-Gomez, G. Lopez-Berestein, and X. Chen
Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia
Blood,
September 1, 2004;
104(5):
1314 - 1323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-X. Shen, Z.-Z. Shi, J. Fang, B.-W. Gu, J.-M. Li, Y.-M. Zhu, J.-Y. Shi, P.-Z. Zheng, H. Yan, Y.-F. Liu, et al.
Inaugural Article: All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
PNAS,
April 13, 2004;
101(15):
5328 - 5335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, M. I. Dawson, Y. Ning, L. Polin, R. E. Parchment, T. Corbett, A. N. Mohamed, K.-C. Feng, L. Farhana, A. K. Rishi, et al.
Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog
Blood,
November 15, 2003;
102(10):
3743 - 3752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yang, H. Zhao, S.-W. Li, K. Ahrens, C. Collins, S. Eckenrode, Q.-g. Ruan, R. A. McIndoe, and J.-X. She
Gene Expression Profiling during All-trans Retinoic Acid-Induced Cell Differentiation of Acute Promyelocytic Leukemia Cells
J. Mol. Diagn.,
November 1, 2003;
5(4):
212 - 221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Shaw, M. Elholm, and N. Noy
Retinoic Acid Is a High Affinity Selective Ligand for the Peroxisome Proliferator-activated Receptor {beta}/{delta}
J. Biol. Chem.,
October 24, 2003;
278(43):
41589 - 41592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. K. Mann, A. Rephaeli, A. L. Colosimo, Z. Diaz, A. Nudelman, I. Levovich, Y. Jing, S. Waxman, and W. H. Miller Jr.
A Retinoid/Butyric Acid Prodrug Overcomes Retinoic Acid Resistance in Leukemias by Induction of Apoptosis
Mol. Cancer Res.,
October 1, 2003;
1(12):
903 - 912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Manor, E. N. Shmidt, A. Budhu, A. Flesken-Nikitin, M. Zgola, R. Page, A. Yu. Nikitin, and N. Noy
Mammary Carcinoma Suppression by Cellular Retinoic Acid Binding Protein-II
Cancer Res.,
August 1, 2003;
63(15):
4426 - 4433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kusmartsev, F. Cheng, B. Yu, Y. Nefedova, E. Sotomayor, R. Lush, and D. Gabrilovich
All-trans-Retinoic Acid Eliminates Immature Myeloid Cells from Tumor-bearing Mice and Improves the Effect of Vaccination
Cancer Res.,
August 1, 2003;
63(15):
4441 - 4449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-W. Li, D. Tang, K. P. Ahrens, J.-X. She, R. C. Braylan, and L. Yang
All-trans-retinoic acid induces CD52 expression in acute promyelocytic leukemia
Blood,
March 1, 2003;
101(5):
1977 - 1980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Maeno, T. Tanaka, Y. Sando, T. Suga, Y. Maeno, J. Nakagawa, T. Hosono, M. Sato, H. Akiyama, S. Kishi, et al.
Stimulation of Vascular Endothelial Growth Factor Gene Transcription by all trans Retinoic Acid through Sp1 and Sp3 Sites in Human Bronchioloalveolar Carcinoma Cells
Am. J. Respir. Cell Mol. Biol.,
February 1, 2002;
26(2):
246 - 253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. I. Gabrilovich, M. P. Velders, E. M. Sotomayor, and W. M. Kast
Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells
J. Immunol.,
May 1, 2001;
166(9):
5398 - 5406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. Lutz, A. Houzel-Charavel, C. Moog-Lutz, and Y. E. Cayre
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid
Blood,
April 15, 2001;
97(8):
2449 - 2456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Niitsu, Y. Ishii, A. Matsuda, and Y. Honma
Induction of Differentiation of Acute Promyelocytic Leukemia Cells by a Cytidine Deaminase-resistant Analogue of 1-{beta}-D-Arabinofuranosylcytosine, 1-(2-Deoxy-2-methylene-{beta}-D-erythro-pentofuranosyl)cytidine
Cancer Res.,
January 1, 2001;
61(1):
178 - 185.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Almand, J. I. Clark, E. Nikitina, J. van Beynen, N. R. English, S. C. Knight, D. P. Carbone, and D. I. Gabrilovich
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer
J. Immunol.,
January 1, 2001;
166(1):
678 - 689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Kogan, S.-h. Hong, D. B. Shultz, M. L. Privalsky, and J. M. Bishop
Leukemia initiated by PMLRARalpha : the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable
Blood,
March 1, 2000;
95(5):
1541 - 1550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.H. Jansen, M.C. de Ridder, W.M.C. Geertsma, C.A.J. Erpelinck, K. van Lom, E.M.E. Smit, R. Slater, B.A. v. Reijden, G.E. de Greef, P. Sonneveld, et al.
Complete Remission of t(11;17) Positive Acute Promyelocytic Leukemia Induced by All-trans Retinoic Acid and Granulocyte Colony-Stimulating Factor
Blood,
July 1, 1999;
94(1):
39 - 45.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick and J. D. Licht
Deconstructing a Disease: RAR{alpha}, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
Blood,
May 15, 1999;
93(10):
3167 - 3215.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Johnson, R. A. S. Chandraratna, R. A. Heyman, E. A. Allegretto, L. Mueller, and S. J. Collins
Retinoid X Receptor (RXR) Agonist-Induced Activation of Dominant-Negative RXR-Retinoic Acid Receptor alpha 403 Heterodimers Is Developmentally Regulated during Myeloid Differentiation
Mol. Cell. Biol.,
May 1, 1999;
19(5):
3372 - 3382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Freedman
Transcriptional Targets of the Vitamin D3 Receptor–Mediating Cell Cycle Arrest and Differentiation
J. Nutr.,
February 1, 1999;
129(2):
581 - 581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Ding, Y.-P. Li, L. M. Nobile, G. Grills, I. Carrera, E. Paietta, M. S. Tallman, P. H. Wiernik, and R. E. Gallagher
Leukemic Cellular Retinoic Acid Resistance and Missense Mutations in the PML-RARalpha Fusion Gene After Relapse of Acute Promyelocytic Leukemia From Treatment With All-trans Retinoic Acid and Intensive Chemotherapy
Blood,
August 15, 1998;
92(4):
1172 - 1183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Collins
Acute Promyelocytic Leukemia: Relieving Repression Induces Remission
Blood,
April 15, 1998;
91(8):
2631 - 2633.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Ketley, P. D. Allen, S. M. Kelsey, and A. C. Newland
Modulation of Idarubicin-Induced Apoptosis in Human Acute Myeloid Leukemia Blasts by All-Trans Retinoic Acid, 1,25(OH)2 Vitamin D3, and Granulocyte-Macrophage Colony-Stimulating Factor
Blood,
December 1, 1997;
90(11):
4578 - 4587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Gallagher, C. L. Willman, J. L. Slack, J. W. Andersen, Y.-P. Li, D. Viswanatha, C. D. Bloomfield, F. R. Appelbaum, C. A. Schiffer, M. S. Tallman, et al.
Association of PML-RARalpha Fusion mRNA Type With Pretreatment Hematologic Characteristics But Not Treatment Outcome in Acute Promyelocytic Leukemia: An Intergroup Molecular Study
Blood,
August 15, 1997;
90(4):
1656 - 1663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Tenen, R. Hromas, J. D. Licht, and D.-E. Zhang
Transcription Factors, Normal Myeloid Development, and Leukemia
Blood,
July 15, 1997;
90(2):
489 - 519.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A.C. Pratt, D. Deonarine, C. Teixeira, D. Novosad, B. F. Tate, and J. F. Grippo
The AF-2 Region of the Retinoic Acid Receptor alpha Mediates Retinoic Acid Inhibition of Estrogen Receptor Function in Breast Cancer Cells
J. Biol. Chem.,
August 23, 1996;
271(34):
20346 - 20352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. Castleberry, P. D. Emanuel, K. S. Zuckerman, S. Cohn, L. Strauss, R. L. Byrd, A. Homans, S. Chaffee, R. Nitschke, and R. J. Gualtieri
A Pilot Study of Isotretinoin in the Treatment of Juvenile Chronic Myelogenous Leukemia
N. Engl. J. Med.,
December 22, 1994;
331(25):
1680 - 1684.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Goddard, J Borrow, P. Freemont, and E Solomon
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
Science,
November 29, 1991;
254(5036):
1371 - 1374.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J Borrow, A. Goddard, D Sheer, and E Solomon
Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17
Science,
September 28, 1990;
249(4976):
1577 - 1580.
[Abstract]
[PDF]
|
|
|
|
|
