|
|
 Previous Article | Table of Contents | Next Article 
Acute nonlymphocytic leukemia: heterogeneity of stem cell origin
PJ Fialkow, JW Singer, JW Adamson, K Vaidya, LW Dow, J Ochs and JW Moohr
Four patients with acute nonlymphocytic leukemia who were heterozygous for
the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase (G6PD)
were studied to determine the numbers and types of progenitor cells in
which the disease arose. Both forms of enzyme were found in normal tissues,
but the malignant blast cells showed only one G6PD, indicating that the
disease was clonal at the time of testing. The observations that normal
erythroid cells were present in two young patients at diagnosis and relapse
indicate that the clone suppressed expression of normal granulopoiesis but
did not prevent normal erythroid differentiation. In contrast to this
situation, in two elderly patients, the disease involved stem cells
multipotent for granulocytes, red cells, and platelets. These results
indicate that acute nonlymphocytic leukemia is heterogeneous. In some
patients, the disease is expressed in cells with differentiation restricted
to the granulocyte-monocyte pathway; in others, it involves stem cells
capable of differentiating to granulocytes-monocytes, platelets, and
erythrocytes. This heterogeneity may reflect differences in causation and
could have prognostic and therapeutic importance.
Volume 57,
Issue 6,
pp. 1068-1073,
06/01/1981
Copyright © 1981 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. L. Guzman, C. F. Swiderski, D. S. Howard, B. A. Grimes, R. M. Rossi, S. J. Szilvassy, and C. T. Jordan
Preferential induction of apoptosis for primary human leukemic stem cells
PNAS,
December 10, 2002;
99(25):
16220 - 16225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. G. Wulf, R.-Y. Wang, I. Kuehnle, D. Weidner, F. Marini, M. K. Brenner, M. Andreeff, and M. A. Goodell
A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia
Blood,
August 15, 2001;
98(4):
1166 - 1173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Bianco, B. J. Farmer, R. E. Sage, and A. Dobrovic
Loss of red cell A, B, and H antigens is frequent in myeloid malignancies
Blood,
June 1, 2001;
97(11):
3633 - 3639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. R. Appelbaum, J. M. Rowe, J. Radich, and J. E. Dick
Acute Myeloid Leukemia
Hematology,
January 1, 2001;
2001(1):
62 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Nilsson, I. Astrand-Grundstrom, I. Arvidsson, B. Jacobsson, E. Hellstrom-Lindberg, R. Hast, and S. E. W. Jacobsen
Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level
Blood,
September 15, 2000;
96(6):
2012 - 2021.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Miyamoto, I. L. Weissman, and K. Akashi
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
PNAS,
June 20, 2000;
97(13):
7521 - 7526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Blair, D.E. Hogge, and H.J. Sutherland
Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71-/HLA-DR-
Blood,
December 1, 1998;
92(11):
4325 - 4335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Ailles, B. Gerhard, and D. E. Hogge
Detection and Characterization of Primitive Malignant and Normal Progenitors in Patients With Acute Myelogenous Leukemia Using Long-Term Coculture With Supportive Feeder Layers and Cytokines
Blood,
October 1, 1997;
90(7):
2555 - 2564.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Blair, D.E. Hogge, L.E. Ailles, P.M. Lansdorp, and H.J. Sutherland
Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo
Blood,
May 1, 1997;
89(9):
3104 - 3112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Duesberg
Activated proto-onc genes: sufficient or necessary for cancer?
Science,
May 10, 1985;
228(4700):
669 - 677.
[Abstract]
[PDF]
|
|
|
|
|
|
|
HEMATOLOGY COMMITTEE
Hematology: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers
Ann Intern Med,
September 1, 1982;
97(3):
459 - 465.
[Abstract]
[PDF]
|
|
|
|
|
