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Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo

S Pollack and S Ruocco

Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.

Volume 57, Issue 6, pp. 1117-1118, 06/01/1981
Copyright © 1981 by The American Society of Hematology


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  Copyright © 1981 by American Society of Hematology         Online ISSN: 1528-0020