|
|
 Previous Article | Table of Contents | Next Article 
A clinicopathologic correlation of the idiopathic hypereosinophilic
syndrome. I. Hematologic manifestations
MA Flaum, RT Schooley, AS Fauci and HR Gralnick
A retrospective blind study of 32 patients with the hypereosinophilic
syndrome was undertaken utilizing a hematologic scoring system that was
based on peripheral blood and bone marrow findings, cytogenetics B12
levels, and leukocyte alkaline phosphatase determinations. In addition to
the grading system, which allowed formulation of a hematologic score, the
date could also be normalized for individuals who did not have all tests
performed by use of the hematologic quotient. This study clearly defined
two groups of patients within the idiopathic hypereosinophilic syndrome.
One group were those individuals with low hematologic scores and quotients
who did not require therapy or who responded to prednisone therapy, while
the second group of patients required cytotoxic therapy. These patients had
significantly higher hematologic scores and quotients and a significant
number of abnormalities similar to those seen in myeloproliferative
syndromes, such as myelofibrosis and cytogenetic abnormalities. This type
of hematologic scoring seems useful in predicting therapy and/or evaluating
individuals or groups of patients with the hypereosinophilic syndrome.
Volume 58,
Issue 5,
pp. 1012-1020,
11/01/1981
Copyright © 1981 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Thiele
Philadelphia Chromosome-Negative Chronic Myeloproliferative Disease
Am J Clin Pathol,
August 1, 2009;
132(2):
261 - 280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Blauwet, J. F. Breen, W. D. Edwards, and K. W. Klarich
Atypical Presentation of Eosinophilic Endomyocardial Disease
Mayo Clin. Proc.,
August 1, 2005;
80(8):
1078 - 1084.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Gotlib, J. Cools, J. M. Malone III, S. L. Schrier, D. G. Gilliland, and S. E. Coutre
The FIP1L1-PDGFR{alpha} fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
Blood,
April 15, 2004;
103(8):
2879 - 2891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Arm and E. J. Mark
Case 30-2000- A 25-Year-Old Man with Asthma, Cardiac Failure, Diarrhea, and Weakness of the Right Hand
N. Engl. J. Med.,
September 28, 2000;
343(13):
953 - 961.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nadarajah, B. Krafchik, C. Roifman, and C. Horgan-Bell
Treatment of Hypereosinophilic Syndrome in a Child Using Cyclosporine: Implication for a Primary T-cell Abnormality
Pediatrics,
April 1, 1997;
99(4):
630 - 630.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Lombardi, C. Rusconi, P. Faggiano, G. Lanzani, C. Campana, and E. Arbustini
Successful Reduction of Endomyocardial Fibrosis in a Patient with Idiopathic Hypereosinophilic Syndrome: A Case Report
Angiology,
April 1, 1995;
46(4):
345 - 351.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Varon, M. Wetzler, and A. Berrebi
Hypereosinophilic Syndrome Associated With Polycythemia Vera
Arch Intern Med,
July 1, 1986;
146(7):
1440 - 1441.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Elouaer-Blanc, E.-S. Zafrani, J.-P. Farcet, M.-F. S.-M. Girardin, D. Mathieu, and D. Dhumeaux
Hepatic Vein Obstruction in Idiopathic Hypereosinophilic Syndrome
Arch Intern Med,
April 1, 1985;
145(4):
751 - 753.
[Abstract]
[PDF]
|
|
|
|
|
