Hemophilic dog model for evaluating therapeutic effectiveness of plasma
protein fractions
HS Kingdon and TM Hassell
Therapeutic effectiveness of factor VIII inhibitor bypassing materials has
been evaluated in dogs with hemophilia A. A standardized template gingival
biopsy was performed using local anesthesia. Hemophilic dogs bled
extensively from the biopsy site, whereas in normal dogs the wound was
sealed within 5 + /- 2 min. If untreated, the hemophilic dogs frequently
bled for several days. Factor VIII infusion stopped the bleeding promptly.
Some experimental preparations of factor VIII inhibitor bypassing materials
were shown to be therapeutically effective, whereas others were not.
Intravascular thrombi could not be demonstrated histologically. The model
should prove useful for evaluating factor VIII inhibitor bypassing
materials and also for evaluating their mechanism of action.
Volume 58,
Issue 5,
pp. 868-872,
11/01/1981
Copyright © 1981 by The American Society of Hematology
