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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Charache, S. Articles by Walker, W. G. Search for Related Content PubMed PubMed Citation Articles by Charache, S. Articles by Walker, W. G. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Failure of desmopressin to lower serum sodium or prevent crisis in patients with sickle cell anemia S Charache and WG Walker An analogue of arginine vasopressin (desmopressin, DDAVP) was evaluated for production chronic hyponatremia and prevention of sickle cell crisis. With sodium restriction (100 meq Na + / day) and water loading ( greater than 3 liters/day), persistent hyponatremia could not be achieved, nor could crises be prevented or aborted. Patients would not comply with a regimen of lower salt and higher fluid intake. More rigorous treatment might be practical during acute sickle cell crises, and a regimen similar to that used here might be more effective in children, whose renal concentrating mechanisms are still intact. Volume 58, Issue 5, pp. 892-896, 11/01/1981 Copyright © 1981 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. B. Haddy and O. Castro Overt Iron Deficiency in Sickle Cell Disease Arch Intern Med, September 1, 1982; 142(9): 1621 - 1624. [Abstract] [PDF]

	Copyright © 1981 by American Society of Hematology         Online ISSN: 1528-0020