|
|
 Previous Article | Table of Contents | Next Article 
Modulation of erythrocyte-endothelial interactions and the vasocclusive
severity of sickling disorders
RP Hebbel, CF Moldow and MH Steinberg
The abnormal adherence of sickle erythrocytes to cultured human vascular
endothelium varies among patients and correlates with vasocclusive severity
within and among the different sickling disorders. For individual patients,
the development of an acute vasocclusive event is not accompanied by an
increase in the inherent propensity for their erythrocytes to adhere to
endothelium. However, the onset of vasocclusion appears to be associated
with the appearance of plasma factors, such as fibrinogen, which enhance
the adherence of sickle erythrocytes to endothelium. In addition, sickle
erythrocytes adhere even more avidly to injured endothelium and under
hyperosmolar conditions. Thus, the overall clinical severity of the
sickling disorders appears to correlate with the inherent propensity for
sickle erythrocytes to adhere to endothelium, and changes in the red cells'
environment may help precipitate crises by the sudden facilitation of
erythrocyte/endothelial interactions.
Volume 58,
Issue 5,
pp. 947-952,
11/01/1981
Copyright © 1981 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Johnson and M. J. Telen
Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease
Haematologica,
April 1, 2008;
93(4):
481 - 485.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. West, P. S. Romano, R. Azari, A. Rudominer, M. Holman, and S. Sandhu
Impact of Environmental Tobacco Smoke on Children With Sickle Cell Disease
Arch Pediatr Adolesc Med,
December 1, 2003;
157(12):
1197 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Belcher, C. J. Bryant, J. Nguyen, P. R. Bowlin, M. C. Kielbik, J. C. Bischof, R. P. Hebbel, and G. M. Vercellotti
Transgenic sickle mice have vascular inflammation
Blood,
May 15, 2003;
101(10):
3953 - 3959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. I. Hammerman, E. S. Klings, K. P. Hendra, G. R. Upchurch Jr., D. C. Rishikof, J. Loscalzo, and H. W. Farber
Endothelial cell nitric oxide production in acute chest syndrome
Am J Physiol Heart Circ Physiol,
October 1, 1999;
277(4):
H1579 - H1592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Manodori, N. M. Matsui, J. Y. Chen, and S. H. Embury
Enhanced Adherence of Sickle Erythrocytes to Thrombin-Treated Endothelial Cells Involves Interendothelial Cell Gap Formation
Blood,
November 1, 1998;
92(9):
3445 - 3454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Cines, E. S. Pollak, C. A. Buck, J. Loscalzo, G. A. Zimmerman, R. P. McEver, J. S. Pober, T. M. Wick, B. A. Konkle, B. S. Schwartz, et al.
Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders
Blood,
May 15, 1998;
91(10):
3527 - 3561.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. N. Poillon, B. C. Kim, and O. Castro
Intracellular Hemoglobin S Polymerization and the Clinical Severity of Sickle Cell Anemia
Blood,
March 1, 1998;
91(5):
1777 - 1783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J.-M. Thevenin, I. Crandall, S. K. Ballas, I. W. Sherman, and S. B. Shohet
Band 3 Peptides Block the Adherence of Sickle Cells to Endothelial Cells In Vitro
Blood,
November 15, 1997;
90(10):
4172 - 4179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. I. HAMMERMAN, S. KOUREMBANAS, T. J. CONCA, M. TUCCI, M. BRAUER, and H. W. FARBER
Endothelin-1 Production during the Acute Chest Syndrome in Sickle Cell Disease
Am. J. Respir. Crit. Care Med.,
July 1, 1997;
156(1):
280 - 285.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. S. Johnson
Sickle Cell Anemia
JAMA,
October 11, 1985;
254(14):
1958 - 1963.
[Abstract]
[PDF]
|
|
|
|
|
