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Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras:
contribution of yolk sac and intraembryonic stem cells
O Lassila, C Martin, P Toivanen and F Dieterlen-Lievre
Lymphocyte development and ontogenetic changes in erythroid cells have been
studied in chick-chick yolk-sac-embryo chimeras differing at the B locus
antigens. Erythroid cells derived from the yolk sac or from the
intraembryonic mesenchyme were demonstrated by indirect immunofluorescence
in the peripheral blood of these allogenic chimeras. At 7 days of
incubation, yolk-sac-derived red cells represent a majority in the
peripheral blood. From 9 days of incubation onwards, embryo-derived
erythrocytes appear in increasing proportions, making up approximately 90%
of the peripheral blood cells at 17-18 days of development. After hatching,
no yolk-sac-derived erythrocytes are found in the peripheral blood. Such a
change from the yolk-sac-derived cells into embryo-derived cells was not
observed in the lymphocytes, as analyzed using specific anti-B and anti-la
antisera for detection of thymus and bursa cells, respectively. Ia-like
antigens were detected on bursa cells using a triple layer
immunofluorescence system. These results obtained from the allogeneic
chimeras indicate that the early chicken yolk sac produces only transiently
erythroid stem cells, while intraembryonic stem cells are involved in the
production of definitive erythrocytes as well as of lymphocytes, both of T
and B cells.
Volume 59,
Issue 2,
pp. 377-381,
02/01/1982
Copyright © 1982 by The American Society of Hematology
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