Acute leukemia in idiopathic sideroblastic anemia: response to combination
chemotherapy
KK Hussein, Z Salem, SS Bottomley and RB Livingston
Three patients with idiopathic sideroblastic anemia of variable duration
developed acute leukemia. In two the leukemia was morphologically and
histochemically myeloblastic, in one lymphoblastic. With combination
chemotherapy remission was achieved in all three. The remission inductions
were complicated by long periods of bone marrow suppression and the
duration of remissions was brief (3, 2 and 3 months). Survival after
diagnosis was 13, 10 and 9 mo, respectively. The ring sideroblast
abnormality persisted during the leukemic and remission phases and
transfusion requirements remained unaltered in the two patients with
transfusion dependent anemia throughout their courses.
Volume 59,
Issue 3,
pp. 652-656,
03/01/1982
Copyright © 1982 by The American Society of Hematology
