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CP Worman, PC Beverley and JC Cawley
Culture studies of peripheral blood mononuclear cells from 7 entirely
typical cases of hairy cell leukemia showed that after culture in the
presence of PHA for 2--5 days, the predominant cell type changed from E-
SIg+ CIg+ gamma FcR+ muFcR+ hairy cells to an E+ SIg- CIg- gamma FcR-
muFcR- population of transformed cells derived from hairy cells. Depletion
and readdition experiments demonstrated that cell-to-cell contact with T
cells was necessary for the phenotypic change, while several observations
indicated that the E+ population was not derived from T cells present
before culture. The E positivity of the cultured cells was shown to be due
to the possession of E receptor not acquired from the culture fluid, but
the cells differed from true T cells in lacking both mature and immature
T-cell antigens. The relevance of these in vitro observations to the
continuing controversy concerning the nature of the hairy cell and to the
in vivo fluctuations in immunologic phenotype not infrequently observed in
hairy cell leukemia is briefly discussed.
This article has been cited by other articles:
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| Copyright © 1982 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
