Emergence of B-immunoblastic sarcoma in patients with multiple myeloma: a
clinicopathologic study of 10 cases
B Falini, I De Solas, AM Levine, JW Parker, RJ Lukes and CR Taylor
Immunologic and histologic studies were performed in 10 cases of myeloma
that showed progression to a more aggressive proliferation, designated as
immunoblastic sarcoma of B-cell type (B-IBS). Several patterns of clinical
presentation were observed: eight patients showed typical multiple myeloma,
four developed B-IBS within the bone marrow, and four developed B-IBS in
multiple extramedullary sites; the remaining two patients had relatively
localized myeloma, but also showed development of extramedullary B-IBS. The
implications of these findings are discussed with regard to their
prognostic import and their relationship to current concepts of plasma cell
development.
Volume 59,
Issue 5,
pp. 923-933,
05/01/1982
Copyright © 1982 by The American Society of Hematology
