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Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid
quantitation
EJ Norman, OJ Martelo and MD Denton
A study was made to assess the value of cobalamin deficiency detection
through quantitation of urinary methylmalonic acid (MMA). Urinary MMA was
measured in 1118 patients suffering from megaloblastic anemia, other
anemias, elevated red cell mean corpuscular volume, or unexplained
neurologic disorders. Patients without proven cobalamin deficiency had
urinary MMA levels less than 20 micrograms/ml. All patients (n = 27)
confirmed to have cobalamin deficiency showed MMA levels greater than 20
micrograms/ml. Data are presented showing the Schilling test results, the
comparison of serum cobalamin to urinary MMA levels, and other basic
hematologic data. MMA levels are a good indication of cobalamin
distribution and function since they are directly related to a
cobalamin-dependent metabolic pathway. With rapid, reliable quantitation by
mass spectrometry, urinary MMA can now be a useful clinical test.
Volume 59,
Issue 6,
pp. 1128-1131,
06/01/1982
Copyright © 1982 by The American Society of Hematology
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