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T-cell subpopulations identified by monoclonal antibodies after human
marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets
K Atkinson, JA Hansen, R Storb, S Goehle, G Goldstein and ED Thomas
Peripheral blood helper-inducer and cytotoxic-suppressor T-cell
subpopulations in patients receiving marrow transplants for the treatment
of acute leukemia or severe aplastic anemia were quantitated on the
fluorescence-activated cell sorter (FACS) using the monoclonal antibodies
OKT4 and OKT8, respectively. The relative (percent) and absolute number of
OKT4+ cells were severely and persistently depleted for up to 2.7 yr
posttransplant. In contrast, the percent and absolute number of OKT8+ cells
began to recover within the first 60 days of transplant and subsequently
remained at normal or high levels for periods of up to 7.3 yr. There was no
significant difference in percent or absolute numbers of OKT8+ cells for
patients with or without acute graft-versus-host disease (GVHD). The
reversal of the normal OKT4:OKT8 ratio (2:1) occurred regardless of whether
the recipient was given an allogeneic, syngeneic, or autologous transplant
and regardless of whether or not acute or chronic GVHD developed. The
reversed ratio was due in the first 3 mo posttransplant to low numbers of
OKT4+ cells and later to a combination of low numbers of OKT4+ and high
numbers of OKT8+ cells. Normalization and then an increase in the number of
OKT8+ cells correlated with increasing time posttransplant and not with
resolution of acute GVHD.
Volume 59,
Issue 6,
pp. 1292-1298,
06/01/1982
Copyright © 1982 by The American Society of Hematology
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