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Synthesis of fibronectin by the isolated perfused rat liver
MR Owens and CD Cimino
The major site(s) of synthesis of plasma fibronectin is unknown. Using the
isolated perfused rat liver and anti-rat fibronectin antiserum, we have
measured net hepatic synthesis of fibronectin during 10-hr perfusion
periods. We calculated the circulating plasma fibronectin pool of a 195-g
rat with body surface area of 300 sq cm to be 3.3 mg: net hepatic synthesis
of 3.75 +/- 1.0 mg/300 sq cm body surface area of the rat liver donor was
seen in liver perfusions of 10 hr. When the hormones cortisol and insulin
were added to the liver perfusate, net synthesis of 5.05 +/- 0.82 mg/300 sq
cm was seen. Synthesis of two known acute phase reactant proteins,
fibrinogen and alpha-2 acute phase globulin, was also substantially greater
in the presence of cortisol and insulin. Plasma fibronectin levels measured
in intact rats that had abscess produced by subcutaneous turpentine
injection were 0.57 +/- 0;05 mg/ml compared to 0.38 +/- 0.02 mg/ml in
normal control animals. Our studies indicate that hepatic synthesis
contributes substantially to the plasma fibronectin pool and show that such
synthesis is enhanced by the hormones cortisol and insulin. In the intact
rat, inflammation was associated with elevated levels of plasma
fibronectin.
Volume 59,
Issue 6,
pp. 1305-1309,
06/01/1982
Copyright © 1982 by The American Society of Hematology
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