Blood, 1951, Vol. 6, No. 6, pp. 504-512.
© 1951 American Society of Hematology, Inc.
The Effects of Triethylene Melamine and Related
Compounds on the Leukocytes of Mouse Leukemia
JOSEPH H. BURCHENAL M.D.1,
LORRAINE F. WEBBER B.A.1,
JUNE L. BIEDLER B.A.1,
G. MARIE MEIGS B.A.1, and
GODFREY D. STOBBE M.D.1
1 Division of Experimental Chemotherapy of the Sloan-Kettering Institute for
Cancer Research, Memorial Cancer Center, New York, N. Y.
1. In the usual therapeutic dosage in mice with the Ak4 strain of leukemia,
TEM caused a prolongation of survival time, held the total leukocyte count
down at severely leukopenic levels, delayed the appearance of immature lymphocytes in the peripheral blood, and caused a marked delay in the appearance of
leukemic infiltrations of the liver, spleen, bone marrow and kidney.
2. A single massive dose of TEM, administered on the seventh day of the
disease when the total leukocyte count was high, caused a rapid fall in the count
and depressed the number of prolymphocytes in the peripheral blood.
3. Single massive doses of such structurally related compounds as hexamethylene diethylenurea, 2,4-diethylenimino-6-amino-s-triazine, and to a lesser degree,
2-ethylenimino-4,6-dimethoxy-s-triazine caused a similar fall in the total leukocyte count when administered on the seventh day of the disease.
