Factor VIII/von Willebrand factor binding to von Willebrand's disease
platelets
HR Gralnick, SB Williams, BC Shafer and L Corash
A form of von Willebrand's disease has been described with enhanced
ristocetin-induced platelet aggregation and anodal migration of the factor
VIII/von Willebrand factor protein (type IIb). We studied two families with
this form of von Willebrand's disease and macrothrombocytopenia. We have
found that these platelets bind more of the normal and intermediate-sized
multimers of the factor VIII/von Willebrand factor than normal platelets.
Analysis of the binding data show an increased affinity of these vWd
platelets for the factor VIII/von Willebrand factor. These findings are
consistent with an increased number of platelet receptors, which, either by
their native topography or migration on the platelet surface, bind factor
VIII/von Willebrand factor protein with greater affinity than normal
platelets, platelets of other vWd patients, and large platelets of other
etiologies.
Volume 60,
Issue 2,
pp. 328-332,
08/01/1982
Copyright © 1982 by The American Society of Hematology
