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Expression of a chronic granulomatous disease-like defect by fluoride- exhausted neutrophils

Y Matzner, LM Brass, BJ McMurrich, WA Peters, J Andre-Schwartz and BM Babior

Neutrophils incubated with 20 mM F- express a respiratory burst without degranulating or performing phagocytosis. After 60 min of F- treatment, the burst is exhausted and cannot be restarted. Neutrophils so treated have a microbicidal defect similar to that of chronic granulomatous disease (CGD): they kill Str. mitis at a nearly normal rate, but show a marked impairment in the destruction of S. aureus. They differ from CGD neutrophils in that they also display a defect in motility. This defect, however, is not so severe as to seriously impair their ability to kill bacteria by mechanisms that are independent of endogenously generated microbicidal oxidants.

Volume 60, Issue 4, pp. 822-826, 10/01/1982
Copyright © 1982 by The American Society of Hematology


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  Copyright © 1982 by American Society of Hematology         Online ISSN: 1528-0020