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Chromosome aberrations in T lymphocytes carrying adult T-cell leukemia- associated antigens (ATLA) from healthy adults

S Fukuhara, Y Hinuma, YI Gotoh and H Uchino

Chromosomes were studied in cultured T lymphocytes carrying adult T- cell leukemia-associated antigens (ATLA) that were obtained from five Japanese anti-ATLA seropositive healthy adults. Chromosomally abnormal cells were observed in three of the five healthy adults, and these cells were clonal in two subjects. All cells examined in one subject had rearrangements of chromosome nos. 7 and 14. Clonal cells from the second had a minute chromosome of unknown origin. A few cells in the third had nonclonal rearrangements of chromosomes. Thus, ATLA-positive T lymphocytes in some anti-ATLA seropositive healthy people have chromosome aberrations.

Volume 61, Issue 1, pp. 205-207, 01/01/1983
Copyright © 1983 by The American Society of Hematology


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  Copyright © 1983 by American Society of Hematology         Online ISSN: 1528-0020