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The secretion of plasminogen activators by human myeloid leukemic cells in
vitro
EL Wilson, P Jacobs and EB Dowdle
Peripheral blood cell preparation from 23 normal subjects and 72 patients
with acute and 32 patients with chronic myeloid leukemia were cultured in
vitro and released plasminogen activators were analyzed. The quantity of
plasminogen activator secreted by leukemic cells varied widely and could
not be correlated with the clinical severity of the disease. Immunochemical
and electrophoretic techniques have been used to show that normal
peripheral blood granulocytes released exclusively urokinase-like
plasminogen activator, whereas leukemic cells secreted either urokinase or
a tissue activator-like enzyme. The molecular species of enzyme released by
acute myeloid leukemic cells may serve as a diagnostic marker of relevance
to the management of this disease, since patients with acute myeloid
leukemia whose cells released only tissue plasminogen activator did not
respond to combination chemotherapy. Tissue plasminogen activators released
by leukemic cells may display an unusual electrophoretic pattern that
resembles that shown by urokinase. Immunochemical procedures are therefore
essential for the correct identification of these enzymes.
Volume 61,
Issue 3,
pp. 568-574,
03/01/1983
Copyright © 1983 by The American Society of Hematology
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