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Selective expression of the common acute lymphoblastic leukemia (gp 100)
antigen on immature lymphoid cells and their malignant counterparts
MF Greaves, G Hariri, RA Newman, DR Sutherland, MA Ritter and J Ritz
The selectivity of monoclonal antibody J-5 (anti-gp 100, common ALL
antigen) for normal and leukemic hemopoietic cells has been investigated.
J-5 gave concordant reactions with rabbit anti-cALL, coredistributed on the
cell surface, and precipitated a similar if not identical glycoprotein from
leukemic and normal tissue. Normal, immature lymphoid cells reactive with
J-5 were detected in bone marrow and in fetal thymus. In marrow they were
largely coincident with the TdT+ population. J-5 defines a major subgroup
of ALL (common ALL) with a favorable prognosis. Of 853 non-ALL acute
leukemias investigated, 80 were J-5 positive. These included 14 cases
diagnosed as AML, 51 TdT+ blast crises of CGL, and 15 cases diagnosed as
"AUL." Of the 14 J-5+ AML, 13 were subsequently rediagnosed either as cALL
(10 cases) or mixed lymphoid-myeloid leukemias (3 cases). One-hundred
forty-three cases of mature lymphoid cell leukemia (91 B, 52 T) were
investigated with J-5; 3 cases only, of disseminated B lymphoma, were
positive, albeit weakly. A higher proportion of follicular lymphomas are,
however, J-5 positive when studied in sections of biopsy material. A
similar pattern of selective reactivity was observed in a series of
leukemia/lymphoma cell lines. These studies emphasize the diagnostic value
of monoclonal anti-cALL reagents.
Volume 61,
Issue 4,
pp. 628-639,
04/01/1983
Copyright © 1983 by The American Society of Hematology
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