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Chronic lymphocytic leukemia progenitor cells carry the antigens T65, BA-1,
and Ia
RT Perri, I Royston, TW LeBien and NE Kay
CLL B cells may be induced to form B-cell colonies in vitro. Colonies
formed are monoclonal and appear to reflect the circulating malignant B-
cell clone in vitro. Using hybridoma-produced monoclonal antibodies (MAB)
and an in vitro B-cell colony assay, we have provided a characterization of
the antigenic phenotype of the clonogenic CLL B cell. B-cell colony growth
in both patients and normals was not altered by prior incubation with
either MAB or complement (C') alone. CLL B- cell colony formation was
markedly reduced after treatment with T101 and C', while normal colonies
were unaffected (8 +/- 2 versus 107 +/- 10). None of the residual CLL
B-cell colonies after T-101 and C' treatment reacted with T-101. However,
BA-1 and la reactivity were still seen in residual CLL B-cell colonies
following T-101 treatment. In contrast, a similar percentage reduction of
B-cell colony growth was seen for both normals and CLL patients following
treatment with BA-1 (76% versus 81%) and Q5/13 (89% versus 92%). These
studies suggest that the CLL progenitor cell is characterized by the
phenotype la+, BA-1+, T- 101+. Better definition of the CLL progenitor cell
has potential implications with regards to clinical utilization of MAB in
the treatment of CLL.
Volume 61,
Issue 5,
pp. 871-875,
05/01/1983
Copyright © 1983 by The American Society of Hematology
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