Fetal erythropoiesis in juvenile chronic myelocytic leukemia
SF Travis
Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine
triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic
myelocytic leukemia (JCML) at the onset of his illness and 6 mo later
during the accelerated phase. The activities of the age-dependent red cell
enzymes, hexokinase, aldolase, pyruvate kinase, and glucose-6- phosphate
dehydrogenase, were elevated, as were the concentrations of red cell
2,3-DPG and ATP, consistent with a young red cell population metabolizing
at an increased glycolytic rate. The activities of the non- age-dependent
enzymes, glyceraldehyde-3-phosphate dehydrogenase (G3PD), phosphoglycerate
kinase, and enolase, were also increased to levels similar to or greater
than those observed in term infants. As the illness progressed, the
activity of red cell G3PD increased further, and phosphoglucose isomerase
activity increased markedly. These results are consistent with the prior
suggestion that JCML represents a reversion to "fetal" erythropoiesis.
Volume 62,
Issue 3,
pp. 602-605,
09/01/1983
Copyright © 1983 by The American Society of Hematology
