Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of
normal and anemic subjects
R Somoza and E Beutler
Red cell phosphoglycolate phosphatase (PGP) and 2,3-diphosphoglycerate
(2,3-DPG) were investigated in normal and anemic patients and rabbits. In
hemolytic anemia and blood-loss anemia, characterized by a young red cell
population, there was an increase in both phosphoglycolate phosphatase
activity and 2,3-diphosphoglycerate levels. In aplastic anemia, the
phosphoglycolate phosphatase activity was normal, but the
2,3-diphosphoglycerate values were nonetheless increased. Thus, no
relationship was found between phosphoglycolate phosphatase activity and
2,3-diphosphoglycerate levels. The lack of correlation between the activity
of phosphoglycolate phosphatase and 2,3-DPG levels suggests that modulation
of phosphoglycolate phosphatase activity does not control the level of
2,3-DPG in erythrocytes.
Volume 62,
Issue 4,
pp. 750-753,
10/01/1983
Copyright © 1983 by The American Society of Hematology
