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RM Winslow, WM Butler, JA Kark, HG Klein and W Moo-Penn
We studied two young army recruits with erythrocytosis. One had a variant
hemoglobin with high affinity for oxygen (hemoglobin Osler, also known as
Fort Gordon and Nancy, beta 145 Tyr leads to Asp). The other had normal
oxygen affinity and erythrocytosis of undetermined etiology. Both were
asymptomatic. We studied exercise capacity on a cycle ergometer before and
after hemodilution. In the subject with high oxygen affinity, hemodilution
resulted in reduced maximal work and increased heart rate at every work
level. In addition, minute ventilation and arterial lactic acid increased,
while anaerobic threshold decreased, indicating diminished oxygen supply to
tissues. In contrast, the subject with normal oxygen affinity had no
significant changes in exercise performance after hemodilution. These
results suggest that when blood oxygen affinity is high, loss of efficiency
in tissue oxygenation can be expected after phlebotomy or hemodilution.
Therefore, it may be useful to measure blood oxygen affinity and exercise
performance in polycythemic subjects in whom such procedures are intended
to ameliorate symptoms of hyperviscosity.
This article has been cited by other articles:
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| Copyright © 1983 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
