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K Sheibani, SJ Forman, CD Winberg and H Rappaport
Although rare cases of chronic lymphocytic leukemia (CLL) of the T-cell
type have been reported, CLL is more commonly found to be a neoplastic
lymphoproliferative disease of B-cell origin. In this article, we describe
a patient with long-standing CLL that was immunologically shown to be of
the B-cell type, who, during the course of his disease, developed cutaneous
T-cell lymphoma (CTCL), which was shown to be of the helper/inducer
subtype. The neoplastic lymphoid cells in the skin infiltrate differed
morphologically and immunologically from those in the peripheral blood. The
occurrence of CTCL during this patient's clinical course represents a
second neoplasm arising from a different cell line, rather than a tissue
manifestation of the patient's CLL. To our knowledge, this is the first
report in which the occurrence of CTCL is documented in a patient with
immunologically known B-cell CLL. In addition to establishing the presence
of B-cell CLL and CTCL of the helper/inducer T-cell type in the same
patient, this case report demonstrates the usefulness and necessity of
evaluating lymphoproliferative disorders by means of a multidisciplinary
approach.
This article has been cited by other articles:
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| Copyright © 1983 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
