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Adult hemoglobins are synthesized in murine fetal hepatic erythropoietic
cells
PM Wong, SW Chung, JS White, SM Reicheld, M Patterson, BJ Clarke and DH Chui
The hemoglobins present in murine fetal hepatic erythroblasts on days 12-15
of gestation were studied by biochemical and immunocytologic techniques. In
addition, fetal hepatic hemopoietic progenitor cells obtained from normal
and mutant f/f mouse fetuses on days 11-13 of gestation were cultured in
vitro with added erythropoietin and adult spleen cell conditioned medium to
form large erythroid colonies. In all instances, adult hemoglobin synthesis
was detected in the fetal hepatic erythroblasts and in the erythroid cell
cultures in vitro. The tumor promoter, 12-O-tetradecanoylphorbol
13-acetate, enhanced the fetal hepatic erythroid colony growth in vitro,
but did not alter the hemoglobin phenotypic expression.
Volume 62,
Issue 6,
pp. 1280-1288,
12/01/1983
Copyright © 1983 by The American Society of Hematology
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