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Ph1-positive acute lymphoblastic leukemia with a 14q+ chromosome abnormality

T Maekawa, Y Sonoda, M Taniwaki, S Misawa, T Abe and T Takino

A 13-yr-old Japanese female with acute lymphoblastic leukemia (ALL) that was associated with a Philadelphia chromosome (Ph1) as well as a 14q+ chromosome abnormality is reported. The cell surface phenotype of leukemic cells was determined to be non-T, non-B ALL on the basis of positive Ia-like antigen, terminal deoxynucleotidyl transferase activity, and lack of receptors for sheep erythrocytes, surface immunoglobulin, or intracytoplasmic mu-chain immunoglobulin. The combination of both a Ph1 and a 14q+ has not been reported previously in patients with ALL.

Volume 63, Issue 2, pp. 310-313, 02/01/1984
Copyright © 1984 by The American Society of Hematology


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  Copyright © 1984 by American Society of Hematology         Online ISSN: 1528-0020