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Diminished activity of a chemotactic inhibitor in synovial fluids from
patients with familial Mediterranean fever
Y Matzner, RE Partridge, M Levy and BM Babior
Synovial fluids from patients with osteoarthritis contain a chemotactic
inhibitor that acts by antagonizing the complement-derived chemotactic
anaphylotoxin, C5a. The activity of this inhibitor in synovial fluids from
patients with several forms of inflammatory arthritis (rheumatoid
arthritis, systemic lupus erythematosus, ankylosing spondylitis, and gout)
were comparable to the activity present in osteoarthritic synovial fluids.
In contrast, levels of inhibitory activity in synovial fluids from 9
patients with familial Mediterranean fever were decreased to less than 20%
of those found in osteoarthritis fluids. The possibility was considered
that the diminished inhibitory activity in fluids from patients with
familial Mediterranean fever plays a part in the pathogenesis of the
inflammatory attacks characteristic of this disease.
Volume 63,
Issue 3,
pp. 629-633,
03/01/1984
Copyright © 1984 by The American Society of Hematology
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